The antibiotic should be applied to the wound prior to the application of Collagenase Santyl Ointment. SANTYL Ointment is the only enzymatic method of debridement shown to uniquely help move wounds toward closure. Abstract. ; 2016. [Google Scholar] Figure 1. Improvement in overall wound appearances; 20% granulation tissue throughout both wounds. To calculate the estimated amount of Collagenase SANTYL Ointment your patient’s wound requires, simply enter its dimensions and duration of. Santyl must be applied at least daily or more often if dressing becomes saturated or soiled (eg incontinence). 2010; 7: 87-95. Bacterial collagenase isolated from Clostridium histolyticum is a selective enzymatic agent that causes hydrolytic cleavage of collagen. The prevalence of malnutrition increases with age, as do chronic wounds. Materials and Methods: A total of 100 patients with infected wounds were treated with topical application of 1% acetic acid as dressing material after appropriate cleaning. Chemical burn: Thigh Treatment Sharp debridement and once daily application of SANTYL Ointment for 35 days. If your wound is large, or if you have several wounds, you may need more than one tube of Santyl. calculator Important Safety Information Indications: Collagenase SANTYL Ointment (“SANTYL”) is a prescription-only medication indicated for debriding chronic dermal ulcers and severely burned areas. (2) Formula to Calculate Length of Gel to Be Applied Daily . 0 for. Based on your specialty or patients’ needs, browse our products and solutions for key features and benefits, technique or application guidance and supporting clinical evidence. Santyl is available in a topical ointment form, in the following doses: 250 units/gram. Sharp debridement was performed at each visit. 125% moistened gauze. 2 – Whenever infection is present, it is desirable to use an appropriate topical antibiotic powder. 0cm; 8. Size. 5cm x 2. Apply the alginate dressing. Contraindications: SANTYL is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. Medial wound measures 15cm x 8. Santyl. 3 – Collagenase Santyl Ointment may be applied directly to the wound or to a sterile gauze pad which is then applied to the wound and properly secured. This was a two-phase study comparing collagenase to hydrogel. of Collagenase SANTYL® Ointment should be terminated when debridement is complete and granulation tissue is well established. , the wound should be cleansed of debris and digested material prior to application of Santyl; whenever infection is present, an appropriate topical antibiotic powder should be used prior to the application of Santyl) CONTINUATION OF THERAPY: Collagenase Santyl Ointment should be discontinued until remission of the infection. 0cm depth. Do you have questions about wound care? We can help. Other Medication Day 6. Apply once daily at 2mm thickness or about the thickness of a nickel. J Burns Wounds. Assess the wound to identify the right treatment or intervention. These side effects may go away during treatment as your body adjusts to the medicine. 85% red and moist wound bed. J Burns Wounds. Edge to edge. Collagenase SANTYL Ointment [prescribing information]. . Wound bed preparation: the science behind the removal of barriers to healing. 80% slough. Shi L, Carson D. Published online: 6 January 2017. Dublin, Feb. 5cm (minimal undermining) New granulation tissue present. ; 2016. Fort Worth, TX: Smith & Nephew, Inc. Online Calculator: After inputting the wound length and width for each of the two wounds and the 20-day treatment duration, you will see that 45 g would be needed. Nonselective methods include M echanical and S harp debridement. (A) Day 7 wound mφ were harvested from PVA sponges coated with CSO (300 mg) implanted. o Search the internet using the terms “Santyl coupon”. Wound presentation. Please note that the estimates are only intended as a guide, contain rounded values where appropriate, and assume a. 5 • Good for moderately to heavily exudative wounds and hemorrhagic wounds. Other Medication Treatment History: New to Therapy Continuation. Overall, the patient was most likely to have a clean wound bed after 2 and 4 weeks of treatment with collagenase. Free. SANTYL Ointment is used to remove damaged tissue from chronic skin ulcers and severely burned areas. Add moisture, as with a saline moistened gauze, compatible wound. Jan 14, 2015. How to Use the Santyl Dosing Calculator. Documentation that Santyl is being used for wound debridement AND 3. 30 grams 90 grams Quantity sufficient per the manufacturer’s dosing calculator _____grams Apply to wound(s) once a day for _____days with a max of _____grams per day. Enoch S, Harding K. 22% lower. 30 grams 90 grams Quantity sufficient per the manufacturer’s dosing calculator _____grams Apply to wound(s) once a day for _____days with a max of _____grams per day. 6 . Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration. However, the mechanism of action of these dressings remain unclear. Enoch S, Harding K. Disease-specific costs. Collagenase SANTYL Oint. Dosing Made Simple. 30 grams 90 grams Quantity sufficient per the manufacturer’s dosing calculator _____grams Apply to wound(s) once a day for _____days with a max of _____grams per day. Other Medication Treatment History: New to Therapy Continuation. Fort Worth, TX: Smith & Nephew, Inc. Without insurance. Compatible with commonly used wound care products. Collagenase SANTYL Ointment [prescribing information]. Shi et al. Enoch S, Harding K. centimeters. Continued with daily SANTYL Ointment application and dressing changes. Prescriber attests that other general wound care measures are being taken, as appropriate (e. Fort Worth, TX: Smith & Nephew, Inc. 86 for late initiation patients, and SANTYL Ointment costs were $129 lower per patient in the early initiation group. Dosing made simple. Nurs. Reviewed by: Robert Chad Hakim, PharmD, BCCCP. SANTYL Ointment and Dakins 0. Prime member price, 30-day supply. Continue daily wound care dressing changes for home health care. 0cm x 1. When using the calculator enter the wound size and the duration of treatment to get your calculated answers. Selective methods include B iological/ B iosurgical, E nzymatic, and A utolytic debridement. SANTYL* Dosing Calculator is on the top of the list of Health & Fitness category apps on Google Playstore. Shi L, Carson D. Ongoing serous drainage and slough noted on both wounds. 1. 2003;15:213-229. A study previously conducted showed. Patient was non-ambulatory with multiple comorbidities prior to the fall. Collagenase SANTYL Ointment [prescribing information]. 1 Primary Objective The primary objective of this study is to evaluate the non-inferiority of MEDIHONEY® Gel (Active Leptospermum Honey-ALH Gel) compared to (Santyl) Collagenase, two FDA cleared/approved treatments, with respect to the percent reduction of necrotic (including slough and eschar) tissue in the wound at the end of 14. therapy with Collagenase SANTYL® Ointment should be discontinued until remission of the infection. This app had been rated by 4 users. 2 million Americans (10. Physiologically, there are the sequential processes of control of contamination and. Less serious side effects may be more likely, and you may have none. This medicine helps remove dead skin tissue and aid in wound healing. Wounds. 10 days later I thought the contact dermatitis was healed enough to start using the Santyl again with absorbent gauze and expensive soft cloth surgical tape as directed by the wound care specialist and my dr. Even though the up-front cost of 1 tube of santyl is more expensive than a hydrogel, santyl proved to be a more cost-effective in the long-run! Overall cost of santyl collagenase was $2,003 and overall. 2 – Whenever infection is present, it is desirable to use an appropriate topical antibiotic powder. 2 cm/application and wound #2 requires 1. Learn how to apply, access savings, and find out more about the safety and prescribing information of this product. Wounds. For this medicine, the following should be considered:. 1cm (right foot) The wound was sharp debrided and SANTYL Ointment was continued with non. 5cm x 2. MEDIHONEY® Gel Wound & Burn Dressing is indicated for dry to moderately exuding wounds such as: diabetic foot ulcers, leg ulcers (venous insufficiency ulcers, arterial ulcers and leg ulcers of mixed etiology), pressure ulcers (partial- and full-thickness), first- and second-degree partial-thickness burns, donor sites. 56 for 1, 30GM of 250UNIT/GM Ointment. Warning and Precautions: The optimal pH range of collagenase is 6 to 8. Advances in Wound Healing: Exploring Treatment ModalitiesSantyl Ointment 250 units/gm Apply to wound(s) once a day for _____days with a max of _____grams per day. 2010; 7: 87-95. Est. Eleven of the 13 subjects from the collagenase group, and 4 of the 14 subjects from the hydrogel group, entered the portion of the study reported in this paper. Petroleum based dressings and all hydrocarbon-producing products must be evaluated on a case-by-case basis in accordance with the established NFPA 99 2012. 8cm x 15. com. Lateral wound measures 21cm x 8cm x 0. LifeNet featured Dermacell AWM and recently launched Matrion at SAWC. 23. Download SANTYL* Dosing Calculator and enjoy it on your iPhone, iPad, and iPod touch. Santyl Ointment 250 units/gm Apply to wound(s) once a day for _____days with a max of _____grams per day. Collagenase SANTYL Ointment [prescribing information]. Mostly granulation tissue with necrotic subcutaneous tissue visible throughout. 3. , >90%) granulation tissue. Before using Santyl. What is Santyl®? • Santyl is a type of medication that cleans wounds and prepares the way. Collagenase Santyl ointment: a selective agent for wound debridement. Building on the scientific premise. Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration. SANTYL is a topical biologic agent that has a unique mechanism of action and has been shown in other studies to help reduce the overall cost of treating chronic wounds. (a) represents the preoperative status of the patient's wounds. 2003;15:213-229. Plast. • Wound measurements: L: 5. Collagenase promotes the cellular responses to injury and wound healing in vivo. temporary redness or irritation in the skin around the affected area. 66 This approach has not gained wide acceptance in the treatment of. With its unique mechanism of debridement, Collagenase SANTYL Ointment has been shown to help wounds progress toward closure through byproducts that contribute to the migration and proliferation of fibroblasts, keratinocytes and endothelial cells. Using both treatments can promote effective debridement and create an optimal environment for healing. Help for low-income patients | SANTYL Ointment. debridement and daily wound care dressings with SANTYL Ointment aided in successful resolution of a chronic TMA wound in 2 months. Santyl ® product insert indicate that ionic silver and iodine both reduce the enzymatic activity of collagenase contained in the debriding ointment (Table 1). I could not sleep the pain was so bad so at night I replace the Santyl with Solosite Gel so I can sleep. All patients who received selective debride-ment were identified using current procedural terminology (CPT) codes 97578 and 97579, resulting in 4,578 wounds (3,486 non-CCO; 1,093 CCO). This medicine is available only with your doctor's prescription. CCH has been shown effective on diabetic foot ulcers and venous leg ulcers. 0cm x 8. 5 Additionally, some infections will require treatment with antibiotics, which may promoteCollagenase SANTYL Ointment 250 units/gram - Apply daily as directed. 63 SANTYL Ointment prescriptions, compared with 1. MORE expand_more. 2. Shi L, Carson D. Wound Registry. 7cm; 0. A. Post-surgical wound: Abdomen Treatment Daily application of SANTYL Ointment with a non-adherent layer. Shi L, Carson D. Shi L, Carson D. Based on our example above, wound #1 requires 5. Change 1 or 2 times daily. ® Therapy. Clostridium Collagenase Impact on Zone of Stasis Stabilization and Transition to Healthy Tissue in Burns. 68,72,79 In the diabetic foot, debridement with collagenase is more efficacious after at least one episode of sharp debridement and is very effective. Ennis, et al. 1cm (left foot) and 2. 8-11. What's new. COLLAGENASE treats skin ulcers and severe burns. A dry dressing is applied with a 4x4 compression bandage to wound. This study is designed to compare SANTYL® versus hydrogel (SoloSite®) in the treatment of pressure ulcers for participants in a long-term care facility. A dry dressing is applied with a 4x4 compression bandage to wound. Calciphylaxis is a rare but devastating disorder most commonly observed in patients with end-stage renal disease, although it does occasionally develop in patients with acute renal failure, normal renal function, or earlier stages of chronic kidney disease (non-uremic calciphylaxis). The SANTYL dosing. However, you can use your free Santyl coupon at a participating pharmacy and pay only $278. Following surgery, the T portion of the incision was covered with Dermabond™ Prineo™ tape for three weeks. an economic model⁶ was developed to compare the cost of using Veraflo Therapy to traditional wound care options including V. 8cm x 0.